Dr. David Mosely, November 7, 2025
We have learned a lot about how to treat post-traumatic stress disorder. Therapies like Prolonged Exposure (PE) and Cognitive Processing Therapy (CPT) have stood the test of time, backed by decades of strong research and are often celebrated as the gold standards of trauma treatment.
Yet outside of research settings, these same therapies often fail to reach their potential. Studies show that the single most common reason for poor outcomes in PTSD care is not that the treatments don’t work, but that patients simply don’t stay in them long enough to benefit. Meta-analytic data suggest that roughly one in five participants drops out of trauma-focused therapy even under optimal research conditions (Varker et al., 2021).
In real-world military and veteran programs, dropout rates routinely exceed 50%, with many individuals disengaging after only two or three sessions. What is driving this is not a lack of motivation but rather a lack of preparation. Too often, patients are asked to confront overwhelming traumatic memories before their nervous systems are ready to tolerate that level of distress.
In theory, trauma-focused treatments are designed to help individuals safely revisit and reprocess painful memories so that those experiences lose their emotional charge. But in practice, these interventions require an extraordinary capacity for distress tolerance, or the ability to experience fear, sadness, or physiological arousal without fleeing or shutting down.
For many trauma survivors, this capacity has been eroded by years of chronic hyperactivation, avoidance, or emotional numbing. The nervous system has learned that survival means escape. When these patients are placed directly into imaginal exposure or cognitive restructuring exercises without sufficient grounding, the body interprets therapy itself as a new threat.
Researchers studying veterans and active-duty service members have repeatedly observed that distress intolerance, not disbelief in treatment, is the main driver of early dropout (Hoge et al., 2014; Berke et al., 2019). The challenge is not about the science behind these therapies; it’s about the sequence in which we deploy them. In most models, distress tolerance is something expected to develop through exposure, rather than before it. But for many individuals, exposure without having received requisite regulation skills training feels less like healing and more like re-traumatization.
The Systemic Gap Between Readiness and Reality
This gap between what therapy demands and what clients are physiologically equipped to handle has become one of the most critical blind spots in modern trauma care. In a review of large-scale Veterans Affairs (VA) rollouts, Najavits (2015) reported that fewer than 10% of veterans, referred to prolonged exposure (PE) or cognitive processing therapy with exposure (CPT), completed a full course of treatment, with most attending only about five sessions. These same programs required rigorous clinician training, close supervision, and fidelity monitoring, yet dropout remained the rule, not the exception.
The reality is that trauma recovery is not just about cognitive insight or exposure to memories; it is about training a dysregulated nervous system to stay within a window of safety long enough for learning to occur. When distress becomes unmanageable, avoidance kicks in. And once avoidance returns, treatment progress halts. Patients often conclude that “therapy didn’t work,” when in fact their nervous system simply was not conditioned for the level of activation the therapy provoked. Unless this foundational readiness is addressed, no amount of session structure or clinician expertise can solve the problem of dropout.
What makes this problem even more complex is that it is not simply a matter of motivation or access, but rather a physiological mismatch between treatment intensity and nervous system readiness. The traditional model assumes that once someone agrees to therapy, they are prepared to handle its emotional demands. But readiness is not a yes-or-no decision; it’s a measurable, biological state that fluctuates with sleep, stress, and cumulative trauma exposure.
Many trauma survivors enter treatment already functioning at the edge of their window of tolerance, where even minor emotional activation can trigger shutdown or hyperarousal. When these clients are asked to confront distressing memories before their body has relearned how to regulate itself, therapy becomes not just difficult but unsafe. This leads to early dropout, not because patients are resistant, but because their nervous systems are overwhelmed.
Clinicians often feel equally frustrated as they are aware that the therapy is sound in principle but may still end up watching it fail in practice. The result is a system that measures success by protocol fidelity rather than by patient capacity, reinforcing the same cycle of disengagement it hopes to prevent. To close this gap, we have to stop treating readiness as an assumption and start treating it as the first stage of recovery itself.
A Different Kind of Preparation: Training the Body First
While pharmacotherapy has long been considered a standard component of PTSD stabilization, it is clear that medication alone is not sufficient to prepare a person for the emotional demands of trauma-focused therapy. Selective serotonin reuptake inhibitors (SSRIs) remain the most frequently prescribed medications for PTSD, yet their effects are largely symptomatic; they mute distress rather than build tolerance for it. Although this can provide short-term relief, it often leaves clients physiologically unconditioned for follow-on exposure work, creating a fragile dependency on medication rather than developing true regulation capacity.
The 2-Dooz approach is intentionally drug-free, designed to strengthen the body’s intrinsic regulation mechanisms rather than rely on chemical suppression of symptoms. As previously discussed here, this distinction is not trivial: long-term SSRI use (beyond five years) has been associated with increased risk of cardiovascular and hepatic complications, particularly when combined with other medications for chronic pain or sleep. Polypharmacy, meaning the use of multiple medications simultaneously by the same patient, amplifies this risk, adding physiological strain to an already overtaxed system.
By helping clients retrain their own autonomic responses instead of medicating them to dull arousal, 2-Dooz offers a safer, more sustainable path toward readiness. The goal is not to eliminate all discomfort but to help the nervous system learn that distress can be experienced and survived without pharmacological intervention. In this way, we move from symptom masking to skill conditioning, preparing clients to enter trauma therapy with confidence, clarity, and control.
At 2-Dooz, our team believes the next leap forward in trauma therapy is not about reinventing the treatments themselves. The path forward is about strengthening the body’s capacity to handle distress before exposure therapy begins and is about maintaining the acquired control for the long-term, after exposure therapy is completed.
PTSD disrupts the balance between the body’s stress and safety systems, leaving individuals vulnerable to physiological overload during therapy. By training clients to recognize and regulate subtle physiological shifts, they can begin to rebuild the confidence that distress can be observed, tolerated, and mastered.
Strengthening the capacity to handle distress is ideally suited to technology. The 2-Dooz Smart Ring continuously monitors key physiological markers of arousal, while our Distress Symptoms Mitigation (DSM) App responds in real time. When the system detects early signs of sympathetic activation before a panic spike or flashback it prompts the user through personalized grounding or breathing exercises. Over time, this feedback loop transforms distress from a threat signal into a training opportunity. The body learns that activation can rise and fall safely, and the mind begins to trust that difficult emotions are survivable. This physiological conditioning sets the stage for trauma therapy to actually work as intended.
Distress Tolerance as a Pre-Treatment Phase
The future of PTSD care should not begin with exposure; it should begin with distress-tolerance conditioning. Just as athletes do not start with full-contact scrimmage, trauma survivors should not be asked to face their most painful memories without first developing the physiological stamina needed to stay present. Building distress-tolerance through the use of technology during the stabilization phase of treatment and maintaining distress-tolerance throughout treatment is paramount; an approach which we call Tactical Calm™.
In practice, this means reframing “readiness” for therapy not as motivation or insight alone, but as measurable autonomic regulation. With continuous data monitoring, clinicians can see when a patient’s baseline stress levels are stabilizing and when the body’s recovery curve after stress exposure shortens—both indicators that the nervous system is learning flexibility. Incorporating this kind of preparatory training into standard treatment protocols could dramatically reduce dropout rates and increase the number of individuals who actually complete evidence-based therapies. In this model, the work of trauma healing becomes less about enduring pain and more about expanding the capacity to experience it safely.
Perhaps the most transformative aspect of physiological monitoring is that it invites patients into a more active partnership with their own recovery. Instead of viewing therapy as something that happens to them once a week, they can see their progress unfold through data. Each calming breath, each recovered spike, each steady night’s sleep becomes visible evidence of resilience being rebuilt. This not only improves engagement but also strengthens the therapeutic alliance, which is a factor that research consistently links to treatment success across all modalities. When clients see that their clinician is not merely interpreting their distress but tracking it alongside them, trust grows. And when that trust is reinforced by tangible physiological feedback, dropout becomes less likely because therapy no longer feels like blind faith. It feels like collaborative, data-driven empowerment.
Real-World Evidence That the Body Can Be Trained
A compelling real-world demonstration of this principle comes from a recent controlled study by Descilo and colleagues (2010) in which adults ages 18 to 65, all with severe PTSD as measured by the PTSD Checklist (PCL), were trained in a yoga-based breathing technique instead of receiving medication. The sample included 160 women and 23 men. Participants in the active treatment group began with a mean baseline PCL-17 score of 66.5, reflecting clinically significant symptoms. Rather than pharmacotherapy, each participant completed eight hours of breath-training, while a control subgroup received delayed treatment.
The results were striking. Within just one week, participants who received the breathing intervention experienced clinically meaningful reductions in PTSD symptoms. After six weeks, the intervention group showed a remarkable 43.2-point average reduction in PCL scores, nearly a 66% improvement from baseline, compared to only 4.6 points in the delayed-treatment control group. To put this in context, a recent Veterans Affairs study found that PTSD medication typically reduces symptoms by only 6.8 to 10.1 points on the PCL scale. In other words, this breath-intervention demonstrated up to a four times greater reduction in PTSD symptoms than medication, without side effects or interference with the development of distress-tolerance skills.
These findings reinforce a critical clinical truth: when the body is trained and equipped to regulate distress autonomically, symptom severity can decrease dramatically, even before traditional trauma-focused therapy begins. Breath-training not only provides immediate relief, but also strengthens the physiological foundation necessary for successful long-term treatment, making it a powerful and safer alternative to medication during the stabilization phase.
Redefining What “Evidence-Based” Should Mean
It is time for the field to expand the definition of evidence-based treatment. A therapy cannot be truly evidence-based if half of the people who need it cannot finish it. As Najavits (2015) argued, the real “gold standard” should be reserved for treatments that demonstrate both strong outcomes in randomized trials and sustained retention in real-world practice.
To reach that standard, mental health care must integrate technologies that enhance readiness, engagement, and endurance. The combination of continuous physiological monitoring and adaptive, real-time intervention can bridge the gap between psychological theory and biological reality. This is not about replacing therapists with technology; it is about equipping therapist with better tools. When the body’s signals are no longer invisible, the clinician can intervene earlier, tailor sessions more effectively, and help patients stay in treatment long enough to reclaim their lives.
Dropout is not a minor inconvenience of PTSD therapy; it is its Achilles’ heel. Every incomplete treatment represents a lost opportunity for recovery, a reinforcement of hopelessness, and often, a confirmation of the belief that “nothing works.” If we want to improve outcomes for trauma survivors, we must start where therapy often fails: in the space between too much and too soon. In my opinion, the next era of mental health care will belong to approaches that blend emotional intelligence with utilization of physiological data and signals.
At 2-Dooz, our mission is to make that future real by building systems that detect distress before it becomes overwhelming. Our solutions guide individuals back to safety in real time, and train the nervous system to tolerate what once felt impossible. The result is not just fewer dropouts; it is a new definition of resilience measured not by avoidance of pain but by the confidence to face it.
Join Us in Redefining Resilience
At 2-Dooz, we are actively partnering with clinicians, researchers, and organizations to integrate physiological monitoring into post-trauma care and to study its effects on engagement and outcomes. If you are a therapist, researcher, or health-tech innovator interested in advancing this work, we would love to connect.
We are currently offering a free opportunity for your patients to participate in a new, drug-free clinical study, which assesses the effectiveness of the Distress Systems Mitigation (DSM) App and 2-Dooz Smart Ring in helping patients to maintain control of their symptoms during the maintenance phase of their care.
By referring a patient to participate in the DSM PTSD Study, you are embracing a unique opportunity to be at the forefront of innovation in PTSD care. Recruitment is officially underway. If you have a patient who is looking for a new, non-drug proactive path to managing their PTSD symptoms, we invite you to learn more.
References
Berke, D. S., Kline, N. K., Wachen, J. S., McLean, C. P., Yarvis, J. S., Mintz, J., ... & Strong Star Consortium. (2019). Predictors of attendance and dropout in three randomized controlled trials of PTSD treatment for active duty service members. Behaviour research and therapy, 118, 7-17.
Descilo, T., Vedamurtachar, A., Gerbarg, P. L., Nagaraja, D., Gangadhar, B. N., Damodaran, B., ... & Brown, R. P. (2010). Effects of a yoga breath intervention alone and in combination with an exposure therapy for post‐traumatic stress disorder and depression in survivors of the 2004 South‐East Asia tsunami. Acta Psychiatrica Scandinavica, 121(4), 289-300.
Hoge, C. W., et al. (2014). PTSD treatment for soldiers after combat deployment: Low utilization of mental health care and reasons for dropout. Psychiatric Services, 65(9), 997–1004.
Najavits, L. M. (2015). The problem of dropout from “gold-standard” PTSD therapies. F1000Prime Reports, 7(43).
Varker, T., Jones, K. A., Arjmand, H. A., Hinton, M., Hiles, S. A., Freijah, I., ... & O'Donnell, M. (2021). Dropout from guideline-recommended psychological treatments for posttraumatic stress disorder: A systematic review and meta-analysis. Journal of Affective Disorders Reports, 4, 100093.
(Disclaimer: This article provides general information and does not constitute medical advice. Treatment decisions for PTSD and related conditions should always be made in consultation with a qualified healthcare professional. If you are, or if you know someone who is in crisis, please seek immediate help by calling or texting the Crisis Line at 988.)